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● ARIZONA
PHOENIX
Fred Arnold, DC, NMD


SCOTTSDALE
Michael Cronin, N.D.
David Tallman, DC, NMD.


TEMPE
Robb D. Bird, NMD


TUCSON
Jorge B. Cochran, ND.NMD

● ARKANSAS
Merl B. Cox, D.O.

BRITISH COLUMBIA
Christoph Kind, N.D.

CALIFORNIA
ANAHEIM AREA
Hanson Wong, M.D.
Howard Rosen, M.D.

AUBURN
Rodney Van Pelt, M.D.

BAKERSFIELD
Payam Kerendian, D.O.


BEVERLY HILLS
Behzad Emad, M.D.
Payam Kerendian, D.O.


CLOVIS
Kevin Wingert, M.D.

FOLSOM
Michele Raithel ND

GARDEN GROVE
Howard Rosen, M.D.

GLENDALE
G. Megan Shields, M.D

IRVINE
Allan Sosin, M.D.

Los Angeles
Donna Alderman, D.O.
Marc Darrow, M.D
Hanson Wong, M.D.


Los GATOS
Joshua M, Donaldson, N.D.

Marin County
Paul Handleman, D.O.
John Monagle, NMD


Monterey
Howard Rosen, M.D.


SAN DIEGO
Andrew Kulik, D.O.

Gary Matson, D.O.

SAN FRANCISCO EAST BAY
Donna Alderman, D.O.

SAN FRANCISCO NORTH BAY
Paul Handleman, D.O.
John Monagle, NMD


San Ramon

Richard I. Gracer, M.D.


SANTA BARBARA
Allen Thomashefsky, M.D.


SANTA CRUZ
Joshua M, Donaldson, N.D.

SANTa monica

Peter Fields, M.D.,D.C.

SANTa
ROSA
Justin Hoffman, NMD

Temecula
Edward A. Venn-Watson, M.D.

UKIAH AREA
Rodney Van Pelt, M.D.

● COLORADO
BOULDER
Gary Clark, M.D.


BROOMFIELD

Christopher J. Centeno, M.D.
John R. Schultz, M.D.


COLORADO SPRINGS
Mary Harrow, D.O,

DENVER
Joel A. Berenbeim, D.O.
Thomas Ravin, M.D.

FORT COLLINS
Mark Kelley, N.D. LAc

LITTLETON
Jo Ann Douglas, M.S.,D.O

PARKER
John A. Littleford, D.O.

STEAMBOAT SPRINGS
Jon Freckleton, D.O.

● CONNECTICUT
AVON
Valley Sports Physicians & Orthopedic Medicine
Paul Tortland, D.O.
Albert Kozar

WEST REDDING

Perry M. Perretz, D.O.

● DELAWARE
SOUTHERN NJ
Scott R. Greenberg, M.D.
SOUTHERN PA
Brian J. Shiple, D.O.

● FLORIDA
ORLANDO AREA
Nelson Kraucak, M.D.


ORMAND BEACH
Hana Chaim, DO

Clearwater
Felix Linetsky, M.D.

PACE
Sheila Mohammed, M.D.

PLANTATION
Alvin Stein,M.D.

SARASOTA/TAMPA BAY
Mark Walter, M.D.
Wellington Chen, M.D.
Matthew Burks, M.D.

TAMPA BAY AREA
Felix Linetsky, M.D.
Robinson Family Clinic

● GEORGIA
WARNER ROBINS
E. Glynn Taunton, D.O.

MARIETTA
Robert C. Shuman, M.D.

Arnold Weil, M.D.

● HAWAII
HAIKU
Kevin Davison, N.D.

HILO

Liza Maniquis-Smigel, MD

Honolulu, Hawaii
Liza Maniquis-Smigel, MD

● ILLINOIS
CHICAGOLAND

Ross Hauser, M.D

PEORIA
Yibing Li, M.D.
Jay Harms, M.D.

WESTERN ILLINOIS
Anwer Rasheed, M.D.

● INDIANA
CLARKSVILLE
Steven M. Johnson, D.O.

LAFAYETTE

Carolyn G. Kochert, M.D.

Mishawaka
Mark S. Cantieri, D.O.,

● IOWA
CLINTON
Anwer Rasheed, M.D.
IOWA CITY
John Macatee, DO.
WEST DES MOINES
Jacqueline M Stoken, D.O

● KANSAS
KANSAS CITY AREA

K. Dean Reeves, M.D.

TOPEKA
Doug Frye, M.D.

● KENTUCKY
LOUISVILLE
Steven M. Johnson, D.O.

● LOUISIANA
NEW ORLEANS AREA
Thomas K. Bond, M.D.

● MARYLAND
Rockville
Ingrid Gheen, M.D.

● MASSACHUSETTS
MALDEN
Albert V. Franchi, M.D.
WORCESTER

Jon Trister, M.D.

● MICHIGAN
EAST LANSING
David Pawsat, D.O.
Howell

Jerald Gach, DO
SHELBY TWP
Robert Krasnick, M.D.
Southfield

Jerald Gach, DO
WARREN

Robert Krasnick, M.D.

● MINNESOTA
EXCELSIOR/Menahga
Mark T. Wheaton, M.D.


MINNETONKA
George H. Kramer, M.D.


● MISSOURI
KANSAS CITY
Edward McDonagh, D.O

ST. Peters
Michael J. Adams


● MONTANA
HAMILTON
Mark Kelley, N.D. LAc

● NEVADA
CARSON CITY

Alfred N. Grimes, M.D.


RENO
Andrew C. Wesely, M.D.

● NEW JERSEY
BLAIRSTOWN
Walter R. Grote, D.O

CENTRAL NJ
Edward Magaziner, M.D.

WAYNE/NORTH NJ
Robert Kramberg, M.D.

SOUTH NJ/
PHILADELPHIA
Scott R. Greenberg, M.D.
(Cherry Hill)

Joseph P. Mullane, M.D.
(Hamilton)


Brian J. Shiple, D.O.
(Springfield PA)

● NEW MEXICO
Albuquerque

R. Dean Bair, D.O.

James E. Baum, D.O.
SANTA FE
James E. Baum, D.O.

Jonas R. Skardis, DOM

● NEW YORK
B
ALDWIN
Pandu Tadoori, M.D.

BUFFALO AREA
Timothy L. Speciale, D.O.
BROOKLYN
Neil Raff, MD, CNS
David Zirkitev, P.A.
EAST MEADOW

Christopher Calapai, D.O.

FLUSHING
Neil Raff, MD, CNS
GOSHEN
Irwin Abraham, M.D.
HICKSVILLE
David Borenstein, M.D.

MANHATTAN
Irwin Abraham, M.D.
Richard Ash, M.D.
David Borenstein, M.D.
John H. Juhl, D.O.
Robert Kramberg, M.D.
NEW YORK METRO AREA
Perry M. Perretz, D.O.
Edward Magaziner, M.D.
Scott R. Greenberg, M.D.
ORANGE
Neil Raff, MD, CNS
ROCKLAND
Neil Raff, MD, CNS
WESTMINSTER
Neil Raff, MD, CNS

● NORTH CAROLINA
ASHEVILLE AREA

Stephen Blievernicht, M.D.
Huntersville
Dr. Mark Hines

● OHIO
AKRON/CANTON
Vladimir Djuric, M.D.
BLUFFTON

L. Terry Chappell, M.D.
CENTERVILLE
Rick Buenaventura, M.D.
CINCINNATI
Michael J. Bertram, MD

Elizabeth Woolford MD
TOLEDO AREA

Jay W. Nielsen, M.D.

● OKLAHOMA
BROKEN ARROW
Shirley J. Welden, M.D.

● OREGON
ASHLAND
Allen Thomashefsky,M.D.
EUGENE
Thomas Peterson, M.D.
HILLSBORO
Kevin C. Wilson, N.D.

LAKE OSWEGO

Noel S. Peterson, N.D.

MEDFORD
Carl Osborn, D.O.
OREGON CITY
Joanne Gordon, ND,MS,PT

PORTLAND

Rick Marinelli, N.D.

Chiaoli Lu, ND. LAc. DAOM.
Patrick Chapman, N.D.
Joshua David, N.D.
REDMOND
E. Payson Flattery, D.C.,N.D.
SALEM
Donald McBride, Jr, ND


● PENNSYLVANIA
BALA CYNWYD
Harvey Kleinberg, D.O.
BETHLEHEM
James F. Frommer, M.D.
ELKINS PARK
Kab S. Hong, M.D.
JEANNETTE
Martin P. Gallagher, M.D., D.C.
MEADVILLE
Paul Peirsel, M.D.
PITTSBURG

Paul S. Lieber, MD
SOUTHERN NJ - PA
Scott R. Greenberg, M.D.
Allan Magaziner, D.O
Edward Magaziner, M.D.
SPRINGFIELD
Brian J. Shiple, D.O.
WOMELSDORF
Peter J Blakemore, D.O,

● SOUTH CAROLINA
GREENVILLE/SPARTANSBURG 
Robert Schwartz, M.D.
CHARLESTON
Marc N. Dubick, M.D.
MOUNT PLEASANT
Patrick Lovegrove, D.O.

● TENNESSEE
BRENTWOOD
Mark L. Johnson, M.D.
CLARKSVILLE
Rafael Prieto, M.D.
JACKSON
Marcus E. Meekins, M.D.
MEMPHIS
Marcus E. Meekins, M.D.
NASHVILLE
Mark L. Johnson, M.D.

● TEXAS
AUSTIN
Mihnea Dumitrescu, M.D.

David K. Harris, M.D.
Brad Fullerton, M.D.
DALLAS
Michael Ellman, M.D.

DENTON
Carlos J. Garcia, M.D.
FORT WORTH
Gerald Harris, DO
Dennis E. Minotti II, D.O
David E. Teitelbaum, D.O.
HOUSTON
Robert Battle, M.D.
Adam Weglein, D.O
HOUSTON AREA

Joseph G. Valdez, M.D

John P. Trowbridge
Shaun Lehmann, M.D.
Curtis Fandrich, D.O.
MESQUITE
Michael Ellman, M.D.
PARIS
Gregg Diamond, M.D.
Norberto Vargas, M.D.
PLANO
Michael Ellman, M.D.
RICHARDSON
Gregg Diamond, M.D.
Norberto Vargas, M.D.

SAN ANTONIO
Annette M. Zaharoff, M.D.
SHERMAN
Gregg Diamond, M.D.
Norberto Vargas, M.D.
SUNNYVALE
Gregg Diamond, M.D.
Norberto Vargas, M.D.



● UTAH
PARK CITY
Harry Adelson, N.D.
Kenneth Hurwitz, M.D.
SALT LAKE CITY
Harry Adelson, N.D.
E. Alan Jeppsen
SPANISH FORK
David Taylor Roberts, M.D

● VERMONT
WINOOSKI
Jonathan E. Fenton, D.O

● VIRGINIA
ALEXANDRIA
Robert H. Wagner, M.D.
BLUEFIELD
Lenny Horwitz, DPM
FAIRFAX
Mayo Friedlis, M.D.
McLEAN
David Wang, D.O.

VIRGINIA BEACH
Lisa Barr, M.D.

● WASHINGTON
ISSAQUAH
Jena Schliiter., M.D.

SEATTLE AREA
Richard A. Sandler, M.D.
JoAnna Forwell, N.D.

Adam R. Geiger, N.D.

● WASHINGTON, D.C.
Ali Safayan, M.D.
● WEST VIRGINIA
MORGANTOWN

Nori Onishi, D.O.


● WISCONSIN
EAU CLAIRE
Deborah Raehl, DO

WAUWATOSA
Neal Pollack, D.O.

MILWAUKEE
William J. Faber, D.O.
 

What is Prolotherapy?
Ross Hauser, M.D.

Prolotherapy is a simple, natural technique that stimulates the body to repair the painful area when the natural healing process needs a little assistance. Notice I said "a little assistance". Because often, that's all the body needs, the rest it can take care of on it's own. In most cases, commonly prescribed
anti-inflammatory medication and more drastic measures like surgery and joint replacement may not help, and often hinder or even prevent the healing process.
 

The basic mechanism of Prolotherapy is simple. A substance is injected into the affected ligaments or tendons, which leads to local Inflammation. The localized inflammation triggers a wound healing cascade, resulting in the deposition of new collagen, the material that ligaments and tendons are made of. New collagen shrinks as it matures. The shrinking collagen tightens the ligament that was injected and makes it stronger. Prolotherapy has the potential of being 100 percent effective at eliminating and chronic pain due to ligament and tendon weakness, but depends upon the technique of the individual Prolotherapy doctor. The most important aspect is injecting enough of the solution into the injured and weakened area. If this is done, the likelihood of success is excellent.
 

Prolotherapy involves the treatment of two specific kinds of tissue: tendons and ligaments. A tendon attaches a muscle to the bone and involves movement of the joint. A ligament connects two bones and is involved in the stability of the joint. A strain is defined as a stretched or injured tendon; a sprain, a stretched or injured ligament. Once these structures are injured, the immune system is stimulated to repair the injured area. Because ligaments and tendons generally have a poor blood supply, incomplete healing is common after injury. This incomplete healing results in these normally taut, strong bands of fibrous or connective tissue becoming relaxed and weak. The relaxed and inefficient ligament or tendon then becomes the source of chronic pain and weakness.
 

The greatest stresses to the ligaments and tendons are where they attach to the bone, the fibro-osseous junction. The most sensitive structures that produce pain are the periosteum (covering of the bone) and the ligaments. It is important to note that in the scale of pain sensitivity (which part of the body hurts more when injured), the periosteum ranks first, followed by ligaments, tendons, fascia (the connective tissue that surrounds muscle), and finally muscle. Cartilage contains no sensory nerve endings. If you are told that your cartilage is the cause of your pain, you have been misinformed; the cartilage cannot hurt because they contain no pain sensing nerves. If there is cartilage damage, the ligaments are typically the structures that hurt. Ligaments are weakest where they attach to bone. The periosteum is the most sensitive area to pain and the ligaments second. It is now easy to understand why this area hurts so much. This is where the Prolotherapy injections occur, and thus eliminate the chronic pain of many conditions including arthritis, mechanical low back pain, degenerative disc disease, cartilage injury, and sports injuries.
 

Prolotherapy works by exactly the same process that the human body naturally uses to stimulate the body's healing system, a process called inflammation. The technique involves the injection of a proliferant (a mild irritant solution) that causes an inflammatory response which "turns on" the healing process. The growth of new ligament and tendon tissue is then stimulated. The ligaments and tendons produced after Prolotherapy appear much the same as normal tissues, except that they are thicker, stronger, and contain fibers of varying thickness, testifying to the new and ongoing creation of tissue. Yes, you heard me right. The ligament and tendon tissue which forms as a result of Prolotherapy is thicker and stronger than normal tissue, up to 40% stronger in some cases!
 

In 1983, Y. King Liu performed a study using the knee ligament in rabbits. This study was done in order to quantify the strength of the tissue formed by Prolotherapy. In this study, a proliferant was injected into the femoral and tibial attachments of the medial collateral ligament, the inside knee ligament. The ligaments were given five prolotherapy treatments and then compared to non-injected ligaments. The results showed that in every case Prolotherapy significantly increased ligamentous mass, thickness, and cross sectional area as well as the ligament strength. In a six-week period, ligament mass increased by 44 percent, ligament thickness by 27 percent, and the ligament bone junction strength by 28 percent. This research was yet another attestation to the effectiveness of Prolotherapy, showing that Prolotherapy actually causes new tissue to grow. Imagine what it would mean to an athlete to run 40 percent faster, jump 40 percent higher, or be 40 percent stronger? This new growth of stronger, healthier tissue is the normal and desired outcome with Prolotherapy.

The concept behind Prolotherapy

The term Prolotherapy was coined by George S. Hackett, M.D., the "father of Prolotherapy", in 1956. He describes Prolotherapy as follows:

"The treatment consists of the injection of a solution within the relaxed ligament and tendon which will stimulate the production of new fibrous tissue and bone cells that will strengthen the weld of fibrous tissue and bone to stabilize the articulation (where the bone and ligament meet) and permanently eliminate the disability. To the treatment of proliferating new cells, I have applied the name 'Prolotherapy' from the word 'Prolo' (Latin) meaning offspring; 'proliferate' - to produce new cells in rapid succession (Websters Dictionary). My definition of Prolotherapy as applied medically in the treatment of skeletal disability is 'the rehabilitation of an incompetent structure by the generation of new cellular tissue.'"

Dr. Hackett, after 20 years of experience, arrived at the conclusion that injured ligaments were the primary cause of chronic pain. Injured tendons were the second most common cause. He referred to this weakness in the ligaments and tendons as laxity. Prolotherapy involves the injection of substances that stimulate new tissue growth at the junction between the fibrous tissue (ligaments and tendons) and the bone. Most things break down at a junction site because this is the weakest part of the structure; this is especially true in weight bearing joints. A good example of this is when the leg of a chair is wobbly or loose. This is usually due to a loose connection where the leg attaches to the seat of the chair. By tightening the attachment of the leg to the seat, the chair becomes more stable.
 

Dr. Hackett used the word "weld," which is a very accurate description of Prolotherapy. Prolotherapy welds the ligaments and tendons to the bone. When welding steel, the welder is applying a very hot probe or flame to melt two pieces of metal together. Two large pieces of metal would require welding many areas all along the long seam. Why do so many spots need to be welded? The reason is to make a stronger connection. If one area weakens in the future due to wear and tear, the others will hold the structure together.
 

This is the concept behind Prolotherapy. All of the injured tissue must be treated for injuries for chronic pain to be eliminated. Prolotherapy causes the proliferation of new ligament and tendon tissue exactly where the injections are given. It is just like spot welding. It strengthens the exact spot where the weld or injection takes place. The more injections, the stronger the weld.

Prolotherapy
Information and Research
Prolotherapy
Prolotherapy
How Does Prolotherapy Work?
Why Does Prolotherapy Work?
How Prolotherapy Helps?
Indications - Contraindications
Introduction to Prolotherapy
Why Get Prolotherapy?
What is Prolotherapy?
How Does Prolotherapy Work?
Are You A Prolo Candidate?

Ligament Reconstruction
How Safe Is Prolotherapy?
Finding a Prolotherapy doctor
When Prolo May Not Work
20 Questions - Prolotherapy
The History of Prolotherapy
Curing Chronic Pain
Sclerotherapy?
Turning to Prolotherapy
Prolotherapy and Chronic Pain
Proof Prolotherapy is Working
Creating Collagen
How To Support Treatment

· Platelet Rich Plasma PRP

Prolotherapy and Inflammation

Prolotherapy In The News
 


Prolotherapy
Videos Online

Prolotherapy to the knee
Back and Spine treatments
Shoulder treatments

· Prolotherapy Information sites

The Journal of Prolotherapy


Prolotherapy Research at
The Journal of Prolotherapy




 

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Getprolo.com cannot guarantee the accuracy of any resources or information from or about the physicians listed on this website.

The opinions and statements in this website DO NOT necessarily reflect the opinions of the physician members of the getprolo.com referral network and are those of the article author only.

A medical testimonial is intended to represent that everyone will obtain the same favorable results from a given therapy. Getprolo.com disclaims any such intention. 

Prolotherapy is a medical technique. As with any medical technique, results will vary among individuals. Prolotherapy injections may not work for you and as with all medical procedures there are risks involved. These risks should be discussed with a qualified health care professional prior to any treatment.

This Prolotherapy information is offered for educational purposes only. Do not act or rely upon the information on this website without seeking independent professional medical advice. 

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